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  Clomiphene
Drug Uses
Clomiphene is a good option for those who wish to become pregnant. It is a fertility medication used in case of irregular ovulation or its absence. The medicine stimulates the release of the hormones necessary for ovulation, it makes the body produce more estrogen in that way it normalizes the process preceding ovulation (may develop mature eggs before it happens).The medicine “deceives” the brain convincing it that the amount of estrogen is not big which encourages the body to produce more. Generally, Clomiphene prepares a woman’s body for pregnancy.
In some cases Clomiphene is used to treat some other medical conditions such as fibrocystic breast, male infertility, constant breast milk production, menstrual problems, sperm problems.
How taken
Clomiphene comes as tablets taken daily by mouth for 5 days, beginning from the 2nd-5th day of menstruation.
You may control your progress either by means of a kit that predicts ovulation that’s sold in any drugstore or by taking basal body temperature.
Doses vary but the treatment usually starts from 50 mg a day five days running. The dose mainly depends on body weight. There is no need to increase the dose unless the first cycle doesn’t turn out to be effective. During the second cycle the dose is increased at 50 mg. It may be increased up to 150 mg as cases when the treatment showed to be successful with the dosage 200-250 mg are very rare.
Precautions
1 Do not exceed the dose prescribed and strictly follow your doctor’s directions.
2 Inform your doctor if you have any allergies before you start the treatment.
3 Before you start the treatment you are to have semen analysis (in order to check any abnormalities in sperm), ovarian ultrasound (to find out if there are any cysts), endometrial biopsy (in order to check if there is cancer or hyperplasia) and also tests to find out any adrenal or thyroid problems, the level of prolactin.
4 Tell the doctor about the medicines you are taking at the moment including vitamins, herbal supplements and others.
5 If the medicine turns to be not effective for you, the doctor may suggest you to combine it with some other medications (gonadotropins, bromocriptine, dexamethasone).
6 Tell the doctor if you are pregnant or you are planning to have a baby. The doctor should also know if you are breast-feeding.
7 Inform the doctor if you have any particular medical conditions especially the following:
Vaginal bleeding
Mental depression
Inflamed veins (because of blood clots)
Thyroid/liver/adrenal problems
Uterine fibroids
Endometriosis
Ovarian cysts, large ovary
Pituitary tumor
8 Do not do anything life-threatening until you find out how your body reacts to the medicine.
9 The medicine may also increase the possibility to cause multiple pregnancy.
10 Because of Clomiphene, multiple follicles may start to develop, so it’s better to visit your doctor regularly. You may also need transvaginal ultrasound to control the situation.
11 If ovulation does not take place after 3 cycles of treatment, additional testing is needed.
12 It’s recommended to have sexual intercourse during a week after a few days you finish taking the medication.
13 Never use the medicine for more than 6 cycles.
14 Do not share your medication with anybody else.
Side effects
Clomiphene may also influence some other organs in your body: the development of the uterine lining may be inadequate; cervical mucous may not thin as it should because of all that estrogen before ovulation. Some women take progesterone to make sure their uterine lining is prepared for that.
The most common side effects are the following: vaginal bleeding, breast tenderness, giddiness, upset stomach, nausea, breast problems, headache, irritation, fatigue, sleep disturbance, flushing, painful menstrual periods. There were cases when ovarian cancer was reported as well as hyperstimulation syndrome.
Among these complications there were the following cases marked: twisting of the ovaries, kidney and liver problems, fluid that’s collected both in the stomach and lungs.
You should also call your doctor if you experience breathlessness, vision problems stomach pain or swelling, weight gain.
Missed dose
If you happen to miss a dose, take it as soon as you can, but if it’s nearly time to take another dose, never double it but phone your doctor and ask for further instructions.
Overdose
Signs of overdose: vision problems, nausea, stomach pain or swelling, upset stomach. Call the emergency immediately if these signs have occurred.
Storage
  • Keep away from children
  • Store at room temperature
  • Keep away from heat, cold and damp places
  • Keep the pills in their container
  • Dispose of an outdated medicine or the one you don’t need any more